I think the essence of it is that melodeon basses dont share reeds, one button opens one pallet for a group of reeds dedicated to that button. The chord voicing can then be chosen, either for ease of manufacture, or to sound good. Stradella mechanism means that all chords are made from the same chromatic reed sets of course. Extra octaves help hide the corners as Paul says.
I think Hohner tend to use reed plates taken from a diatonic scale reed set, so where you have, say G chord one way on the bellows and C chord the other, the reed plates will be one G/G, one B/C and one D/E. The Italian makers use a greater variety of reed plates, partly because if you want a stop to take out the thirds, then the third of the chord both ways has to be on the same plate.
Its a very interesting and quite significant point Sandy. If one was satisfied with fewer basses they could be constructed melodeon-wise, even if the buttons were standard Stradella - how about a piano accordion with just C,G,D,A, Em and B minor or major (since thats all a D/G melodeon has.) That would be an easy reed swap for a 12 bass box. Alternatively, I guess a Stradella mechanism could be built so as to link each octave seperately, giving the designer options as to the most pleasing voicing. Wouldnt free bass mechanisms have separate pallets for each octave?
I dont know whats the largest number of basses that uses a dedicated one button = one reed set relationship. 24 ?