I'm starting to learn the Stradella System, having come from Anglo concertina. I see that there are lot of chord patterns - Major, relative minor, seventh - that are available just using nearby combinations of fundamental and sub-base (rows 1 and 2, without touching the pre-set chord buttons). Is that a bad route to take? It seems to cut out a lot of jumps (e.g. G Maj to Em).
Yes, it's (usually) a bad route to take.
@dunlustin's reply will probably do the trick for you as to why.
The notes used for the bass buttons are (largely) different from the notes used for the chord buttons. Whether on the fundamental row or counter-bass row, the bass notes are typically all arranged within a single, fairly low octave (per reed set).
This does not make for good chord voicing. While you
can formulate chords using the bass notes, they'll be muddy and indistinct compared to the "real" chord buttons, which (mostly) play notes in higher octaves.
There's a reason guitar players strum chords and bass players usually do not, even though it's technically possible for their instruments to do so.
(I'm using a lot of parenthetical here because both bass and chord buttons, as well as the RH, will often play a given "note" in more than one octave at the same time, depending on the register setting, so there can be overlaps as a result. But
generally, your bass buttons are designed to "sound lower" than the notes used for the chord buttons, which are in turn designed to "sound lower" than the RH keys.)